Key to prevention
However, the real breakthrough for the dioxin receptor research occurred at the beginning of this millennium with the insight that the aryl hydrocarbon receptor signalling pathway not only presents the reason for these diseases, but also the key to the treatment or the prevention of the most serious diseases.
Based on the AhR signalling pathway, the pharmaceutical companies or the medical faculties (with the help of external funding by the pharmaceutical industry) have been developing or - with regard to the side effects - further developing drugs against almost every civilization disease such as Alzheimer’s disease, diabetes, ADS or depression and many more.
As a result, and thanks to Poland, the AhR signalling pathway has not only served as lock, but also as key to the realization of, e.g., the development of a chemotherapy with only few side effects or necessary preventive measures such as a ban of hazardous ingredients in our food, or harmful substances in our flats, our cars, at our workplaces and in our environment.
Note: Many publicists / researchers consider the Ah receptor to be the basic principle, a human-toxicological premise.
In order to emphasize the actual importance of the AhR signalling pathway, the German-speaking toxicologists (Kaina, Dietrich, University of Mainz) even used the term “canonical” (according to the rules) primarily used in the ecclesiastical law in their publication with the title “The aryl hydrocarbon receptor (AhR) in the regulation of cell–cell contact and tumor growth” published in 2010.
There is nothing more to be said with regard to the human-toxicological relevance of the Ah receptor signalling pathway (not only in view of the tumor growth rates).