Beispiele der Ursachenforschung sogenannter Zivilisationskrankheiten auf Basis des AhR Signalwegs

Pränatale Entwicklungsdefizite / Vorgeburtliche neuronale (Fehl-)Entwicklung

Over-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells: neurotoxicology study                               
Environ Health. 2006; 5: 24.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570454/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570454/pdf/1476-069X-5-24.pdf

Gene-Chemical Interactions in the Developing Mammalian Nervous System: Effects on Proliferation, Neurogenesis and Differentiation 
Neurotoxicology. 2010 Sep; 31(5): 589–597.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934892/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934892/pdf/nihms210049.pdf

Expression of Aryl Hydrocarbon Receptor in Human Placentas and Fetal Tissues
J Histochem Cytochem. 2010 Aug; 58(8): 679–685.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907273/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907273/pdf/679.pdf

The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development  Developmental Biology Volume 270, Issue 1, 1 June 2004, Pages 64–75
http://www.sciencedirect.com/science/article/pii/S0012160604001198

Effects of Prenatal Exposure to Endocrine Disrupters on Cerebral Cortex Development
Multi-System Endocrine Disruption Research and Perspectives in Endocrine Interactions pp 43-49
http://link.springer.com/chapter/10.1007/978-3-642-22775-2_3

Immunologic and Neurodevelopmental Susceptibilities of Autism
Neurotoxicology. 2008 May; 29(3): 531–544.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475601/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475601/pdf/nihms55471.pdf

Autismus

Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system
http://link.springer.com/article/10.1007/s00109-016-1486-0
http://link.springer.com/content/pdf/10.1007%2Fs00109-016-1486-0.pdf

DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?                        
Environ Epigenet. 2016 Mar; 2(1): dvv012.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856164/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856164/pdf/nihms756677.pdf

Association of Aryl Hydrocarbon Receptor-Related Gene Variants with the Severity of Autism Spectrum Disorders           
Front Psychiatry. 2016; 7: 184.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110561/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110561/pdf/fpsyt-07-00184.pdf

Support for calcium channel gene defects in autism spectrum disorders
https://molecularautism.biomedcentral.com/articles/10.1186/2040-2392-3-18
https://molecularautism.biomedcentral.com/track/pdf/10.1186/2040-2392-3-18?site=molecularautism.biomedcentral.com

Krebs

Sunitinib, a tyrosine kinase inhibitor, induces cytochrome P450 1A1 gene in human breast cancer MCF7 cells through ligand-independent aryl hydrocarbon receptor activation.
https://www.ncbi.nlm.nih.gov/pubmed/23288144

Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation
Molecular Cancer201716:14 DOI: 10.1186/s12943-016-0570-y
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-016-0570-y
https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-016-0570-y?site=molecular-cancer.biomedcentral.com

Autoimmunerkrankungen

The aryl hydrocarbon receptor: a perspective on potential roles in the immune system
Immunology. 2009 Jul; 127(3): 299–311.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712099/pdf/imm0127-0299.pdf

The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response                                               Immunology. 2013 Mar; 138(3): 183–189
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573271/pdf/imm0138-0183.pdf

The Role of AhR in Autoimmune Regulation and Its Potential as a Therapeutic Target against CD4 T Cell Mediated Inflammatory Disorder    
nt J Mol Sci. 2014 Jun; 15(6): 10116–10135
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100143/pdf/ijms-15-10116.pdf

The roles of aryl hydrocarbon receptor in immune responses
Int Immunol (2013) 25 (6): 335-343
https://academic.oup.com/intimm/article/25/6/335/733829/The-roles-of-aryl-hydrocarbon-receptor-in-immune
https://academic.oup.com/intimm/article-pdf/25/6/335/2186716/dxt011.pdf

Aryl hydrocarbon receptor and experimental autoimmune arthritis.
Semin Immunopathol. 2013 Nov;35(6):637-4
https://www.ncbi.nlm.nih.gov/pubmed/23982178

Transplantationsmedizin

Environmental Exposures- The Missing Link in Immune Responses After Transplantation.
Am J Transplant. 2016 May;16(5):1358-64
https://www.ncbi.nlm.nih.gov/pubmed/26696401
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844852/pdf/nihms-744712.pdf