Article Index

Examples for the aetiology of so-called civilization diseases based on the AhR signalling pathway

Prenatal developmental deficits / prenatal neuronal (mal-)development

Over-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells: neurotoxicology study                               
Environ Health. 2006; 5: 24.

Gene-Chemical Interactions in the Developing Mammalian Nervous System: Effects on Proliferation, Neurogenesis and Differentiation 
Neurotoxicology. 2010 Sep; 31(5): 589–597.

Expression of Aryl Hydrocarbon Receptor in Human Placentas and Fetal Tissues
J Histochem Cytochem. 2010 Aug; 58(8): 679–685.

The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development  Developmental Biology Volume 270, Issue 1, 1 June 2004, Pages 64–75

Effects of Prenatal Exposure to Endocrine Disrupters on Cerebral Cortex Development
Multi-System Endocrine Disruption Research and Perspectives in Endocrine Interactions pp 43-49

Immunologic and Neurodevelopmental Susceptibilities of Autism
Neurotoxicology. 2008 May; 29(3): 531–544.


Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system

DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?                        
Environ Epigenet. 2016 Mar; 2(1): dvv012.

Association of Aryl Hydrocarbon Receptor-Related Gene Variants with the Severity of Autism Spectrum Disorders           
Front Psychiatry. 2016; 7: 184.

Support for calcium channel gene defects in autism spectrum disorders


Sunitinib, a tyrosine kinase inhibitor, induces cytochrome P450 1A1 gene in human breast cancer MCF7 cells through ligand-independent aryl hydrocarbon receptor activation.

Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation
Molecular Cancer201716:14 DOI: 10.1186/s12943-016-0570-y

Autoimmune diseases

The aryl hydrocarbon receptor: a perspective on potential roles in the immune system
Immunology. 2009 Jul; 127(3): 299–311.

The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response  
Immunology. 2013 Mar; 138(3): 183–189

The Role of AhR in Autoimmune Regulation and Its Potential as a Therapeutic Target against CD4 T Cell Mediated Inflammatory Disorder    
nt J Mol Sci. 2014 Jun; 15(6): 10116–10135

The roles of aryl hydrocarbon receptor in immune responses
Int Immunol (2013) 25 (6): 335-343

Aryl hydrocarbon receptor and experimental autoimmune arthritis.
Semin Immunopathol. 2013 Nov;35(6):637-4

Transplant medicine

Environmental Exposures- The Missing Link in Immune Responses After Transplantation.
Am J Transplant. 2016 May;16(5):1358-64