Prevention / therapeutic application
Application Resveratrol / Metformin - breast cancer risk / autoimmune diseases
Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.
Toxicol Appl Pharmacol. 2014 Oct 1;280(1):138-48
https://www.ncbi.nlm.nih.gov/pubmed/25110054
Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.
Toxicol Appl Pharmacol. 2015 Apr 15;284(2):217-26
https://www.ncbi.nlm.nih.gov/pubmed/25697376
Effects of metformin on Sirt1, Nrf2 and AhR expression in cancer cells
Department of Pharmacy Graduate School Chungnam National University
A Dissertation for the Degree of Doctor of Philosophy
Autor; Minh Truong Do Advisor Hye Gwang Jeong August 2014
http://lrc.tnu.edu.vn/upload/collection/brief/43413_189201493932dominhtruong.pdf
Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation
Molecular Cancer201716:14
DOI: 10.1186/s12943-016-0570-y
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-016-0570-y
https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-016-0570-y?site=molecular-cancer.biomedcentral.com
Hypertension
Metformin Reverses Development of Pulmonary Hypertension via Aromatase Inhibition
Hypertension. 2016;68:00-00.
http://hyper.ahajournals.org/lookup/suppl/doi:10.1161/HYPERTENSIONAHA.116.07353/-/DC1
Autoimmune reaction / diabetes
Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076843/
Resveratrol protects against polychlorinated biphenyl-mediated impairment of glucose homeostasis in adipocytes
J Nutr Biochem. 2013 Dec; 24(12): 2168–2174.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066417/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066417/pdf/nihms-527453.pdf
Chemotherapy / Resveratrol
Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway.
Arch Toxicol. 2014 Mar;88(3):725-38.
https://www.ncbi.nlm.nih.gov/pubmed/24247421
Autoimmune encephalomyelitis
Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor
Global Research & Development, Teva Pharmaceutical Industries Ltd.,
www.pnas.org/cgi/doi/10.1073/pnas.1607843113
Microbiome
Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system
Journal of Molecular medicine Jan 2017, Volume 95 pp 29-39
https://link.springer.com/article/10.1007/s00109-016-1486-0
https://link.springer.com/content/pdf/10.1007%2Fs00109-016-1486-0.pdf
Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522678/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522678/pdf/srep12689.pdf
Antiviral / AIDS HIV
Constitutive aryl hydrocarbon receptor signaling constrains type I interferon–mediated antiviral innate defense Nature Immunology 17, 687–694 (2016)
http://www.nature.com/ni/journal/v17/n6/abs/ni.3422.html
The aryl hydrocarbon receptor is a modulator of anti-viral immunity
Biochem Pharmacol. 2009 Feb 15; 77(4): 642653.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662440/
Constitutive aryl hydrocarbon receptor signaling constrains type I interferon-mediated antiviral innate defense.
Nat Immunol. 2016 Jun;17(6):687-94
https://www.ncbi.nlm.nih.gov/pubmed/27089381
New insights into the aryl hydrocarbon receptor as a modulator of host responses to infection
Semin Immunopathol. 2013 Nov; 35(6)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808126/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808126/pdf/nihms-518589.pdf
