Article Index

Prevention / therapeutic application

Application Resveratrol / Metformin - breast cancer risk / autoimmune diseases

Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.
Toxicol Appl Pharmacol. 2014 Oct 1;280(1):138-48

Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.
Toxicol Appl Pharmacol. 2015 Apr 15;284(2):217-26

Effects of metformin on Sirt1, Nrf2 and AhR expression in cancer cells
Department of Pharmacy Graduate School Chungnam National University
A Dissertation for the Degree of Doctor of Philosophy
Autor; Minh Truong Do  Advisor Hye Gwang Jeong August 2014

Aryl hydrocarbon receptor/cytochrome P450 1A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and β-Catenin and Akt activation
Molecular Cancer201716:14                                         
DOI: 10.1186/s12943-016-0570-y


Metformin Reverses Development of Pulmonary Hypertension via Aromatase Inhibition
Hypertension. 2016;68:00-00.

Autoimmune reaction / diabetes

Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders

Resveratrol protects against polychlorinated biphenyl-mediated impairment of glucose homeostasis in adipocytes                            
J Nutr Biochem. 2013 Dec; 24(12): 2168–2174.

Chemotherapy / Resveratrol

Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway.   
Arch Toxicol. 2014 Mar;88(3):725-38.

Autoimmune encephalomyelitis

Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor 
Global Research & Development, Teva Pharmaceutical Industries Ltd.,


Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system
Journal of Molecular medicine Jan 2017, Volume 95 pp 29-39

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Antiviral / AIDS HIV

Constitutive aryl hydrocarbon receptor signaling constrains type I interferon–mediated antiviral innate defense  Nature Immunology 17, 687–694 (2016)

The aryl hydrocarbon receptor is a modulator of anti-viral immunity
Biochem Pharmacol. 2009 Feb 15; 77(4): 642653.

Constitutive aryl hydrocarbon receptor signaling constrains type I interferon-mediated antiviral innate defense.                                       
Nat Immunol. 2016 Jun;17(6):687-94

New insights into the aryl hydrocarbon receptor as a modulator of host responses to infection
Semin Immunopathol. 2013 Nov; 35(6)